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bd40bc7c7a With reference to the evaluation of prophylaxis, 14/22 courses were reported as having an excellent outcome (13 frequent and one infrequent administration), five were effective (four frequent and one infrequent) and two partly effective (frequent). Eur J Haematol. 2003;1 (10):2153-8.OpenUrlCrossRefMedlineWeb of Science41.Mariani G, Dolce A, Batorova A, Auerswald G, Schved JF, Siragusa S, et al. Plasma-derived factor VII concentrates Four courses of prophylaxis with pd-FVII concentrates were given to three patients (age range, 5-25 years). The patient whose efficacy evaluation was reported as partly effective received 42 g/kgrFVIIa. 2007;79(4):354-9.OpenUrlCrossRefMedline39.Nicolaisen EM.
The former group of patients mainly experience mucosal bleeding, a clinical picture that mimics that of a platelet disorder and does not call for prophylaxis. In contrast, for the most severely affected patients, a group whose condition is characterized by life- or limb-threatening hemorrhages, long-term prophylactic FVII replacement therapy should be considered. The total weekly dose of rFVIIa administered was similar for the excellent (mean, 85.7 g/kg; median, 90 g/kg; range, 30-120 g/kg) and effective (mean, 106.8 g/kg; median, 132 g/kg; range, 40-189 g/kg) outcomes. J Thromb Haemost. 2006;23(2):129-33.OpenUrlCrossRefMedline36.Giansily-Blaizot M, Aguilar-Martinez P, Briquel ME, d'Oiron R, De Maistre E, Epelbaum S, Schved J F.Two novel cases of cerebral haemorrhages at the neonatal period associated with inherited factor VII deficiency, one of them revealing a new nonsense mutation (Ser52Stop). Cookies are required to use this site. 1996;26 (Suppl 1):98-101.OpenUrlMedlineWeb of Science40.Mariani G, Herrmann FH, Schulman S, Batorova A, Wulff K, Etro D, et al. Recombinant activated factor VII schedules based on frequent administrations (three times weekly) and a 90 g/kg total weekly dose were effective. No thrombosis or new inhibitors occurred.